Expertise

Go to Genomics

Genomics

Using massively parallel sequencing the genome sequence can be accurately determined. Depending on your setting and interest the whole genome can be sequenced (even starting from a very limited amount of DNA) or specific genes or regions (e.g. exome sequencing) can be targeted.

Go to Transcriptomics

Transcriptomics

Transcriptomics (or expression profiling) is the study of the complete set of RNA transcripts that are produced by specific cells or tissues under specific circumstances. Messenger RNAs (mRNA), micro RNAs (miRNA), long non-coding RNAs (lncRNA), etc can be sequenced and quantified, allowing differential gene expression analysis.

Go to Epigenomics

Epigenomics

Epigenetics research seeks to describe dynamic alterations in the transcriptional potential of a cell. The main epigenetic mechanisms are DNA methylation, histone modification, DNA accessibility and non-coding RNA-associated gene silencing. NXTGNT has all the tools in house to analyse these epigenetic mechanism in an integrated analysis.

Go to Bioinformatics

Bioinformatics

NXTGNT can help you with your sequencing data analysis with a team of high-skilled experts. We perform data analysis starting from raw sequencing reads, working towards publication-ready results: Statistics, visualization, PCA analysis, Gene-Set Enrichment Analysis, pathway analysis, etc. Feel free to contact us regarding any question.

Go to 10X Genomics single cell and linked-reads

10X Genomics single cell and linked-reads

We provide all single cell and linked-reads sequencing solutions offered by the 10X Genomics Chromium System & GemCode Technology

Go to Cancer precision medicine

Cancer precision medicine

Molecular insights, connecting physicians and their patients to the latest cancer treatment approaches through pharmacogenetics, making precision medicine a reality.

Nanopore sequencing

Oxford nanopore sequences unamplified DNA and RNA, eliminating the need for amplification steps (and the resulting quantitative and qualitative amplification bias). Long reads up to 100 kbp with direct detection of 5-methylcytosines in DNA and N6-methyladenines in RNA provide tremendous advantages in de novo assembly, detection of large structural variants, RNA isomforms, etc.

Can't wait to get things going?

About

NXTGNT
NXTGNT

NXTGNT was founded in 2008 to create a rich and unique substrate for groundbreaking research, development and valorization at Ghent University. The main goal of NXTGNT is the establishment of a reference center for next generation sequencing (NGS), (epi-)genome and transcriptome analysis at Ghent University. NXTGNT established a unique service platform by the integration of a state-of-the-art NGS library preparation facility with several sequencing platforms and a strong expertise in -omics data-analysis (bioinformatics).

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NXTGNT is supported by several Ghent University partners from different faculties:

Our Team

Steering Committee

Filip Van Nieuwerburgh

Steering Committee
Filip Van Nieuwerburgh (Prof. Ph.D. Pharm.D.) heads the UGent Next Generation Sequencing core facility NXTGNT, focusing on transcriptomics, (epi)genomics and bioinformatics. He coordinated the initiative to bring together key experts to create the Expertise Centre for Sequencing

Dieter Deforce

Steering Committee
Dieter Deforce (Prof. Ph.D. Pharm.D.) is the head of the Laboratory for Pharmaceutical Biotechnology in the Faculty of Pharmaceutical Sciences. He is the director of ProGenTomics offering proteomics and genomics services.

Wim Van Criekinge

Steering Committee
Wim Van Criekinge (Prof. Ph.D.) heads Biobix, a Computational Genomics & Bioinformatics laboratory at Ghent University. Wim Van Criekinge is CSO of MDxHealth, a listed biotechnology company active in cancer diagnostics.

Daisy Flamez

Steering Committee
Passionate towards innovation in applied biomarker research, business development and contract management, network and partnering with industrial partners, patent portfolio management, facilitation of obtaining (inter)national innovation funds, licensing, and setup of spin-offs.

Sequencing Operational Team

Sarah De Keulenaer

Project coordination. Sample preparation expert. Financial administration.

Sylvie Decraene

Project coordination. Sample preparation expert. Financial administration.

Ellen De Meester

Project coordination. Sample preparation expert. Financial administration.

Bioinformatics Team

Yannick Gansemans

A biologist, a chemist, and a statistician are out hunting. The biologist shoots at a deer and misses five feet to the left. The chemist takes a shot and misses five feet to the right. The statistician yells “We got ’em!”

Laurentijn Tilleman

If you torture data enough it will confess.

Tim Meese

Bring data! I’ll provide the results.

Sander Willems

How easy is it to count in binary? It’s as easy as 01 10 11.

BIOBIX

The BIOBIX lab of Bioinformatics and Computational Genomics focuses the development of innovative data-analytical methodologies to solve complex biological questions, related to imprinting, CpG mutability, epitranscriptomics, telomere biology, micropeptide biology, cancer, aging studies, neuronal development, crop protection, virus discovery and ecology.